Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Prof. Rakefet Schwarz Laboratory

The Mina & Everard Goodman Faculty of Life Sciences

Research

Our laboratory employs genetic approaches and cutting-edge molecular tools to study mechanisms allowing cyanobacteria to sense changes in the environment and survive under a large variety of conditions. Cyanobacteria had, and still have a substantial impact on life on earth. Being the first organisms that performed ‘oxygenic photosynthesis’, cyanobacteria had a pivotal role in the history of life by changing the chemistry of the atmosphere and allowing the development of aerobic eukaryotes. Furthermore, cyanobacteria are considered the ancestors of chloroplasts of algae and higher plants. Currently, the central ecological importance of cyanobacteria is manifested in their significant contribution to global CO2 fixation (25-30% of global CO2 fixation is attributed to cyanobacteria). Additional major environmental impact stems from cyanobacterial blooms, which affect the entire food chain, and in cases of ‘toxic blooms’ cause the collapse of large aquatic ecosystems and impact the quality of water reservoirs. Our studies of cyanobacterial stress physiology and the molecular mechanisms underlying it, provide insight into fundamental cellular processes, e.g. regulated proteolysis and multicellular behavior of bacteria.

Cyanobacterial Biofilms

Cyanobacterial Biofilms

Biofilms are bacterial communities encased by extracellular matrix produced by the residing bacteria. Cyanobacterial biofilms are environmentally prevalent, and additionally, often occur in an industrial context, imposing damage and leading to financial loss; however, information on cyanobacterial mechanisms involved in biofilm development is scarce. Thus, our studies provide a new cellular context in which to investigate the developmental process of biofilm formation. We recently uncovered a process of self-inhibition of biofilm formation in the cyanobacterium S. elongatus. Additionally, we identified genes essential for biofilm development (see “Our Projects” for details). 

Regulated Proteolysis of the Phycobilisome

Regulated Proteolysis of the Phycobilisome

Cyanobacteria, much like other photosynthetic organisms, adjust their light harvesting apparatus in response to environmental cues. This tuning allows effective light absorbance for the phototrophic metabolism while preventing the deleterious effect of surplus excitation. The phycobilisome, the cyanobacterial pigment antenna, is a supramolecular assembly that may reach 4 MDa. A small protein, NblA, is essential for the degradation of this pigment complex under nutrient limitation. We recently revealed that this small protein associates with phycobilisomes attached to the photosynthetic membranes. We propose that NblA serves a dual function: undermining complex stability and designating the dissociated pigments for degradation (see “Our Projects” for details).

Survival and Death of Aging Cultures

Survival and Death of Aging Cultures

Phytoplankton populations frequently encounter conditions that do not permit cell proliferation e.g. nutrient limitation. Investigation of aging cultures of the cyanobacterium S. elongatus serves to unravel strategies of cell survival as well as cell-death in non-growing cultures. We revealed adaptive plasticity of cell morphology, which is dictated by ambient nutrient status. Additionally, we demonstrated that collapsing aging cultures of S. elongatus produce toxic compounds that effectively kill a large variety of phytoplankton species (see “Our Projects” for details).

Tailoring Cyanobacteria for Biofuel

Tailoring Cyanobacteria for Biofuel

Environmental as well as economic factors call for sustainable alternatives to the use of fossil fuels. Biofuels derived from arable crops are not cost-effective and the impact of these ‘first generation biofuels’ on food supply and price have raised ethical questions. Photosynthetic microorganisms offer an efficient means for biofuel production that is not associated with the current problems of land-based feedstock. We genetically modified S. elongatus in order to increase accumulation of glycogen, a raw material for bioethanol production.

Our team

Prof. Rakefet Sсhwarz

Prof. Rakefet Sсhwarz

Head of Laboratory

Tel: 972-3-531-7790
Fax: 972-3-738-4058
Email: Rakefet.Schwarz@biu.ac.il

Dr. Ella Sendersky

Dr. Ella Sendersky

Research Associate

Ph.D

Email: es@rakefetlab.com

Mali Levi

Mali Levi

PhD student

Email: mm@rakefetlab.com

Yevgeni Yegorov

Yevgeni Yegorov

PhD Student

Email: yy@rakefetlab.com

Eli Zecharia

Eli Zecharia

M.Sc. Student

Email: ez@rakefetlab.com

Shiran Suban

Shiran Suban

M.Sc. Student

Email: su@rakefetlab.com

Hila Kolton

Hila Kolton

M.Sc. Student
E-mail: hk@rakefetlab.com

 

Alumni

Rami Parnasa

Rami Parnasa

M.Sc/Ph.D 

Email: rp@rakefetlab.com

Boris Veltman

Boris Veltman

M.Sc

E-mail: bv@rakefetlab.com

Elad Nagar

Elad Nagar

M.Sc/Ph.D

E-Mail: eladnagar82@gmail.com

Michael Moizik

Michael Moizik

M.Sc

Shaul Zilberman

Shaul Zilberman

M.Sc

Liron Levi-Asiskovich

Liron Levi-Asiskovich

M.Sc

Elad	Hikri

Elad Hikri

Postdoc

Assaf Adlerstein-Cohen

Assaf Adlerstein-Cohen

Ph.D

Elizabeth Ginzberg

Elizabeth Ginzberg

M.Sc

Dr. Ella Sendersky

Dr. Ella Sendersky

Research Associate

Ph.D

Email: es@rakefetlab.com

Daniella Schatz

Daniella Schatz

Postdoc

Tsachi Friedman

Tsachi Friedman

M.Sc

Hagit Goclaw-Binder

Hagit Goclaw-Binder

M.Sc

Roxane Lahmi

Roxane Lahmi

M.Sc

Alexander Perelman

Alexander Perelman

Postdoc

J.B. Bhattacharya

J.B. Bhattacharya

Postdoc

Pavel Sigalevich

Pavel Sigalevich

Postdoc

Yonatan Moskowitz

Yonatan Moskowitz

M.Sc

Yehudit Shealtiel

Yehudit Shealtiel

M.Sc

Avraham Uzan

Avraham Uzan

M.Sc

Contacts

 

 

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Ramat-Gan 5290002

Israel

The Freiman Environmental Biology Building (201), Rooms 03, 04

Rakefet.Schwarz@biu.ac.il

Laba@rakefetlab.com

Waze: http://waze.to/smiruCWYAyf3wY.fqd

Tel: +972 3 5317790

 

 




 

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