We identified genes that are essential for biofilm formation. These genes include small proteins characterized by a double-glycine secretion motif as well as a component of transport system responsible for secretion and maturation of these small proteins.
Sequence of the double-glycine motif of the product of pcc7942_1134 and selected secreted peptides. Cerein7B of Bacillus cereus, EnterocinA and EnterocinB of Enterococcus faceum, MicrocinE492 of Klebsiella pneumonia, and Microcin24, MicrocinH47, and ColicinV of Escherichia coli. Black shading indicates the double-glycine or glycine-alanine present just prior to the peptide cleavage site (arrow).
Scientific Reports –Nature 2016 Aug 25;6:32209
Small secreted proteins enable biofilm development in the cyanobacterium Synechococcus elongatus.
Parnasa R, Nagar E, Sendersky E, Reich Z, Simkovsky R, Golden S, Schwarz R